Efficacy of a mycotoxin binder against dietary fumonisin, deoxynivalenol, and zearalenone in rats.
J Agric Food Chem
; 59(13): 7527-33, 2011 Jul 13.
Article
em En
| MEDLINE
| ID: mdl-21650453
ABSTRACT
It was hypothesized that a mycotoxin binder, Grainsure E, would inhibit adverse effects of a mixture of fumonisin B1, deoxynivalenol, and zearalenone in rats. For 14 and 28 days, 8-10 Sprague-Dawley rats were fed control diet, Grainsure E (0.5%), toxins (7 µg fumonisin B1/g, 8 µg of deoxynivalenol/g and 0.2 µg of zearalenone/g), toxins (12 µg of fumonisin B1/g, 9 µg of deoxynivalenol/g, and 0.2 µg of zearalenone/g + Grainsure E), or pair-fed to control for food intake of toxin-fed rats. After 28 days, decreased body weight gain was prevented by Grainsure E in toxin-fed female rats, indicating partial protection against deoxynivalenol and fumonisin B1. Two effects of fumonisin B1 were partly prevented by Grainsure E in toxin-fed rats, increased plasma alanine transaminase (ALT) and urinary sphinganine/sphingosine, but sphinganine/sphingosine increase was not prevented in females at the latter time point. Grainsure E prevented some effects of fumonisin B1 and deoxynivalenol in rats.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tricotecenos
/
Zearalenona
/
Fumonisinas
/
Dieta
/
Micotoxinas
Limite:
Animals
Idioma:
En
Revista:
J Agric Food Chem
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos