Efficacy and safety of two analogs of L-carnitine on rats made insulin resistant by a high-fructose diet.
Pharmacology
; 88(1-2): 10-7, 2011.
Article
em En
| MEDLINE
| ID: mdl-21709430
ABSTRACT
AIM:
To evaluate the efficacy and safety of 2 analogs of L-carnitine on rats made insulin resistant by a high-fructose diet.METHODS:
Using rats made insulin resistant by a high-fructose diet, we investigated the impact of 2 analogs of L-carnitine (25 mg/kg) and L-carnitine (250 mg/kg) on glucose, triglycerides and cholesterol blood levels, and liver glycogen. We also evaluated the safety of both analogs by the assessment of some biochemical and hematological parameters, a histological analysis and a study of embryotoxicity.RESULTS:
Both analogs reduced the levels of triglycerides in the liver and plasma, but only analog 2 reduced the cholesterol levels in insulin-resistant rats. No changes were observed in glycogen content. Safety evaluations revealed alterations in blood lymphocytes and embryotoxicity data.CONCLUSION:
This study demonstrated that the 2 analogs maintain the pharmacological properties of L-carnitine but have a different efficacy, potency and toxicity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Edulcorantes
/
Complexo Vitamínico B
/
Resistência à Insulina
/
Carnitina
/
Frutose
Limite:
Animals
Idioma:
En
Revista:
Pharmacology
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
México