Concise review: Bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications.
Stem Cells
; 29(2): 169-78, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21732476
ABSTRACT
Transplantation of bone marrow stem cells into spinal cord lesions enhances axonal regeneration and promotes functional recovery in animal studies. There are two types of adult bone marrow stem cell; hematopoietic stem cells (HSCs), and mesenchymal stem cells (MSCs). The mechanisms by which HSCs and MSCs might promote spinal cord repair following transplantation have been extensively investigated. The objective of this review is to discuss these mechanisms; we briefly consider the controversial topic of HSC and MSC transdifferentiation into central nervous system cells but focus on the neurotrophic, tissue sparing, and reparative action of MSC grafts in the context of the spinal cord injury (SCI) milieu. We then discuss some of the specific issues related to the translation of HSC and MSC therapies for patients with SCI and present a comprehensive critique of the current bone marrow cell clinical trials for the treatment of SCI to date.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Traumatismos da Medula Espinal
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Medula Óssea
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Transplante de Medula Óssea
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Transplante de Células-Tronco Hematopoéticas
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Transplante de Células-Tronco Mesenquimais
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Regeneração da Medula Espinal
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Stem Cells
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Reino Unido