Design and characterization of calcium alginate microparticles coated with polycations as protein delivery system.
J Microencapsul
; 28(7): 614-20, 2011.
Article
em En
| MEDLINE
| ID: mdl-21740107
ABSTRACT
Bovine serum albumin (BSA) loaded calcium alginate microparticles (MPs) produced in this study by a w/o emulsification and external gelation method exhibited spherical and fairly smooth and porous morphology with 1.052 ± 0.057 µm modal particle size. The high permeability of the calcium alginate hydrogel lead to a potent burst effect and too fast protein release. To overcome these problems, MPs were coated with polycations, such as chitosan, poly-L-lysine and DEAE-dextran. Our results demonstrated that coated MPs showed slower release and were able to significantly reduce the release of BSA in the first hour. Therefore, this method can be applied to prepare coated alginate MPs which could be an optimal system for the controlled release of biotherapeutic molecules. Nevertheless, further studies are needed to optimize delivery properties which could provide a sustained release of proteins.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poliaminas
/
Soroalbumina Bovina
/
Química Farmacêutica
/
Sistemas de Liberação de Medicamentos
/
Materiais Revestidos Biocompatíveis
/
Alginatos
Idioma:
En
Revista:
J Microencapsul
Assunto da revista:
FARMACIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Espanha