Histone deacetylase inhibitor belinostat represses survivin expression through reactivation of transforming growth factor beta (TGFbeta) receptor II leading to cancer cell death.

Chowdhury, Sanjib; Howell, Gillian M; Teggart, Carol A; Chowdhury, Aparajita; Person, Jonathan J; Bowers, Dawn M; Brattain, Michael G

Chowdhury, Sanjib; Howell, Gillian M; Teggart, Carol A; Chowdhury, Aparajita; Person, Jonathan J; Bowers, Dawn M; Brattain, Michael G.

Afiliação

Chowdhury S; Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska 68198-7696.
Howell GM; Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska 68198-7696.
Teggart CA; Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska 68198-7696.
Chowdhury A; Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska 68198-7696.
Person JJ; Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska 68198-7696.
Bowers DM; Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263.
Brattain MG; Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska 68198-7696. Electronic address: mbrattain@unmc.edu.

J Biol Chem ; 286(35): 30937-30948, 2011 Sep 02.

Article em En | MEDLINE | ID: mdl-21757750

Assuntos

Inibidores de Histona Desacetilases/farmacologia; Ácidos Hidroxâmicos/farmacologia; Proteínas Inibidoras de Apoptose/antagonistas & inibidores; Neoplasias/metabolismo; Proteínas Serina-Treonina Quinases/metabolismo; Receptores de Fatores de Crescimento Transformadores beta/metabolismo; Catálise; Morte Celular; Linhagem Celular Tumoral; Proteínas Quinases Dependentes de AMP Cíclico/metabolismo; Relação Dose-Resposta a Droga; Epigênese Genética; Humanos; RNA Interferente Pequeno/metabolismo; Receptor do Fator de Crescimento Transformador beta Tipo II; Transdução de Sinais; Sulfonamidas; Survivina; Fator de Crescimento Transformador beta/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Receptores de Fatores de Crescimento Transformadores beta / Proteínas Inibidoras de Apoptose / Inibidores de Histona Desacetilases / Ácidos Hidroxâmicos / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2011 Tipo de documento: Article

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