Is the baboon model appropriate for endometriosis studies?
Fertil Steril
; 96(3): 728-733.e3, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-21774926
ABSTRACT
OBJECTIVE:
To determinethe prevalence of spontaneous endometriosis andthe incidence of induced endometriosis after endocervical canal resection in baboons.DESIGN:
Induction and follow-up of endometriosis in baboons, which is one of the primate species that develop spontaneous endometriosis. Forty-one baboons were checked for the presence of spontaneous endometriosis. We then attempted to induce endometriosis in 30 of them by endocervical canal resection.SETTING:
Institute of Primate Research, Nairobi, Kenya, and Catholic University of Louvain, Brussels, Belgium. ANIMAL(S) Forty-one baboons were checked for spontaneous endometriosis and 30 of them were used to develop a model of induced endometriosis. INTERVENTION(S) A total of 41 baboons underwent diagnostic laparoscopy for 10 months. In a first step, 30 of this number subsequently underwent endocervical canal resection. In a second step, 20 of the 30 underwent uterine horn resection. MAIN OUTCOME MEASURE(S) Follow-up by laparoscopy. RESULT(S) Two of the 41 baboons were diagnosed with spontaneous endometriosis (4.8%). Twelve months after the surgical procedure to induce endometriosis, 8 of 29 animals presented with endometriotic lesions diagnosed by using laparoscopy and confirmed by histologic examination. The incidence of induced endometriosis in our model was thus 27.6%. In 2 baboons, endometriosis disappeared over time, resulting in a final rate of 20.7% (6/29). CONCLUSION(S) The rate of spontaneous endometriosis is very low (4.8%). Endometriosis can be induced (with a rate of just 27.6%) by endocervical canal resection to stimulate retrograde menstruation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Papio
/
Modelos Animais de Doenças
/
Endometriose
Tipo de estudo:
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Fertil Steril
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Bélgica