Synthesis and molecular modeling study of new trimeric quinoline derivatives.
Bioorg Chem
; 39(4): 143-50, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21807395
ABSTRACT
Di- and trimeric quinoline derivatives have been recently described as potential modulators of Bcl-2 family protein interactions. However, only a few trimeric compounds have been described so far and an enlargement of the number of analogs of this class is needed to expand the structure-activity relationship study. Therefore, the synthesis of six new trimeric quinoline derivatives is reported. Moreover molecular modeling experiments were performed to study the conformational arrangement of compound 36 in Bak binding site of Bcl-x(L), showing that these compounds could be potential ligands for Bcl-x(L).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinolinas
/
Modelos Moleculares
Idioma:
En
Revista:
Bioorg Chem
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
França