Can circulating interleukin-18 differentiate between sarcoidosis and idiopathic pulmonary fibrosis?
Scand J Clin Lab Invest
; 71(7): 593-7, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-21834618
ABSTRACT
OBJECTIVE:
The aim of the present study was to investigate serum and bronchoalveolar lavage fluid (BALF) interleukin-18 (IL-18) levels in sarcoidosis and idiopathic pulmonary fibrosis (IPF) and to assess the clinical usefulness of IL-18 in these diseases.METHODS:
Serum and BALF levels of IL-18 were measured in 15 patients with sarcoidosis, 10 patients with IPF and 24 control subjects (8 with lung tumor, 6 with pulmonary tuberculosis and 10 healthy controls). Lymphocyte fractions (T, B and natural killer (NK) cells) in blood and BALF were analysed by flow cytometer.RESULTS:
The serum and BALF levels of IL-18 in patients with sarcoidosis were significantly higher (p < 0.05) than those in IPF subjects and control groups. The percentages of T, B and NK cells in blood and BALF did not differ among all groups, while the blood and BALF CD4/CD8 ratios in patients with sarcoidosis were significantly higher (p < 0.05) than those in the other groups. Among all subjects, the serum levels of IL-18 correlated positively with the CD4/CD8 ratios in BALF (r = 0.693, p < 0.001).CONCLUSIONS:
As to the levels of IL-18 in serum and BALF, there were differences between sarcoidosis and IPF indicating a different role of IL-18 in the pathogenesis of these diseases. Measurement of circulating IL-18 might have a potential of clinical utility in the differential diagnosis of sarcoidosis versus IPF.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose Pulmonar
/
Sarcoidose Pulmonar
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Interleucina-18
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Fibrose Pulmonar Idiopática
/
Neoplasias Pulmonares
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Limite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Scand J Clin Lab Invest
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
China