Pharmacokinetics and tissue penetration of vancomycin continuous infusion as prophylaxis for vascular surgery.
J Antimicrob Chemother
; 66(11): 2624-7, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-21840937
ABSTRACT
OBJECTIVES:
To determine the tissue penetration of vancomycin into perivascular fat and arterial wall during a continuous infusion of vancomycin, given as prophylaxis for vascular surgery. PATIENTS ANDMETHODS:
Patients undergoing arterial reconstruction requiring antibiotic prophylaxis were included. Patients received a loading infusion of vancomycin the evening prior to surgery followed by a continuous 24 h infusion, calculated according to renal function. Three peri-operative serum samples and intra-operative perivascular fat and arterial wall samples were collected for vancomycin assay.RESULTS:
Twenty-eight patients were included. Three serum samples were obtained from all patients, fat samples were available from 27 (96.4%) patients and vessel wall samples were available from 23 (82.1%) patients. Serum vancomycin concentrations were maintained within a relatively narrow range, while fat and arterial wall concentrations were highly variable.CONCLUSIONS:
This study has shown that prophylactic administration of vancomycin with a loading infusion followed by a continuous infusion before and during vascular surgery achieves serum and vascular tissue concentrations that are above the MICs for most common organisms implicated in post-operative graft infection. However, penetration into perivascular fat tissues is poor.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artérias
/
Procedimentos Cirúrgicos Vasculares
/
Vancomicina
/
Infecções Relacionadas à Prótese
/
Antibioticoprofilaxia
/
Gordura Subcutânea
/
Antibacterianos
Limite:
Humans
Idioma:
En
Revista:
J Antimicrob Chemother
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Reino Unido