Human cytomegalovirus infection increases mitochondrial biogenesis.
Mitochondrion
; 11(6): 935-45, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-21907833
ABSTRACT
Fibroblasts infected by Human Cytomegalovirus (CMV) undergo a robust increase in mitochondrial biogenesis with a corresponding increase in mitochondrial activity that is partly dependent on the viral anti-apoptotic pUL37x1 protein (vMIA). The increased respiration activity is blocked by the mitochondrial translation inhibitor chloramphenicol, which additionally suppresses viral production. Intriguingly, chloramphenicol and pUL37x1 depletion have different effects on respiration capacity but similar effects on CMV production, suggesting that pUL37x1 promotes viral replication by efficient utilization of new mitochondria. These results argue for a role of pUL37x1 beyond controlling apoptosis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Citomegalovirus
/
Fibroblastos
/
Mitocôndrias
Limite:
Humans
Idioma:
En
Revista:
Mitochondrion
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Noruega