Factors associated with acute gout attacks in normouricaemic gout patients receiving allopurinol: a retrospective study.
Scand J Rheumatol
; 40(6): 444-7, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-21916803
ABSTRACT
OBJECTIVE:
To identify factors associated with acute gout attacks in normouricaemic gout patients receiving allopurinol.METHODS:
We reviewed the medical records of 860 patients with chronic gout who were treated with allopurinol at a single tertiary hospital between 2003 and 2009. Of these, 135 patients had serum urate concentrations ≤ 360 µmol/L (6 mg/dL). Patients whose serum urate concentrations exceeded 360 µmol/L (6 mg/dL) at least once during follow-up were excluded. Patients who experienced at least one acute attack during follow-up, despite normouricaemia [≤ 360 µmol/L (6 mg/dL)], were classified as the Attack group (n = 51). The others were classified as the Non-attack group (n = 84).RESULTS:
The gout disease duration was significantly longer in the Attack group than in the Non-attack group (p = 0.036). The presence of tophi and multiple joint involvement were associated with acute attacks in normouricaemic gout patients. Multivariate analysis showed that both the presence of tophi [odds ratio (OR) 4.16, 95% confidence interval (CI) 1.41-12.23, p = 0.010] and the number of involved joints (OR 1.51, 95% CI 1.05-2.17, p = 0.028) were independently associated with acute attacks in normouricaemic gout patients receiving allopurinol.CONCLUSION:
The presence of tophi and multiple joint involvement were associated with acute attacks in normouricaemic gout patients receiving allopurinol.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alopurinol
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Supressores da Gota
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Gota
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Scand J Rheumatol
Ano de publicação:
2011
Tipo de documento:
Article