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Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases.
Cao, Jingsong; Zhou, Yingjiang; Peng, Haibing; Huang, Xinyi; Stahler, Shannon; Suri, Vipin; Qadri, Ariful; Gareski, Tiffany; Jones, Juli; Hahm, Seung; Perreault, Mylene; McKew, John; Shi, Mengxiao; Xu, Xin; Tobin, James F; Gimeno, Ruth E.
Afiliação
  • Cao J; Biocorrection Research Unit, Pfizer, Cambridge, Massachusetts 02140. Electronic address: jingsong.cao@novartis.com.
  • Zhou Y; Biocorrection Research Unit, Pfizer, Cambridge, Massachusetts 02140.
  • Peng H; Biocorrection Research Unit, Pfizer, Cambridge, Massachusetts 02140.
  • Huang X; Screening Sciences, Pfizer, Collegeville, Pennsylvania 19426.
  • Stahler S; Screening Sciences, Pfizer, Collegeville, Pennsylvania 19426.
  • Suri V; Biocorrection Research Unit, Pfizer, Cambridge, Massachusetts 02140.
  • Qadri A; Biocorrection Research Unit, Pfizer, Cambridge, Massachusetts 02140.
  • Gareski T; Biocorrection Research Unit, Pfizer, Cambridge, Massachusetts 02140.
  • Jones J; Biocorrection Research Unit, Pfizer, Cambridge, Massachusetts 02140.
  • Hahm S; Biocorrection Research Unit, Pfizer, Cambridge, Massachusetts 02140.
  • Perreault M; Biocorrection Research Unit, Pfizer, Cambridge, Massachusetts 02140.
  • McKew J; Exploratory Medicinal Chemistry, Pfizer, Cambridge, Massachusetts 02140.
  • Shi M; Discovery Pharmacokinetics, Pfizer, Andover, Massachusetts 01810.
  • Xu X; Discovery Pharmacokinetics, Pfizer, Andover, Massachusetts 01810.
  • Tobin JF; Biocorrection Research Unit, Pfizer, Cambridge, Massachusetts 02140.
  • Gimeno RE; Biocorrection Research Unit, Pfizer, Cambridge, Massachusetts 02140. Electronic address: gimeno_ruth@lilly.com.
J Biol Chem ; 286(48): 41838-41851, 2011 Dec 02.
Article em En | MEDLINE | ID: mdl-21990351
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Redução de Peso / Inibidores Enzimáticos / Diacilglicerol O-Aciltransferase / Fígado Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2011 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Redução de Peso / Inibidores Enzimáticos / Diacilglicerol O-Aciltransferase / Fígado Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2011 Tipo de documento: Article