Necrosis in breast cancer patients with skin metastases receiving bevacizumab-based therapy.
J Wound Care
; 20(9): 403-4, 406, 408 passim, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-22068139
ABSTRACT
OBJECTIVE:
Bevacizumab has entered daily practice in advanced breast cancer patients, in whom skin metastases occurrence is a common event. Wound healing impairment has been described with bevacizumab, and this study looks at possible deleterious side effects of bevacizumab in patients with skin metastases.METHOD:
We retrospectively reviewed a series of 12 patients with advanced breast cancer presenting extensive skin metastases, and who received bevacizumab based therapy.RESULTS:
Nine patients who initially presented with erosive skin lesions developed extensive and durable skin necrosis, as well as delayed healing of surgical flaps, despite early discontinuation of bevacizumab therapy and intensive skin care in a specialised unit. Skin necrosis was usually associated with extensive tumoural involvement of the skin.CONCLUSION:
Bevacizumab may be harmful in selected breast cancer patients with metastatic cutaneous involvement.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Úlcera Cutânea
/
Neoplasias da Mama
/
Inibidores da Angiogênese
/
Anticorpos Monoclonais Humanizados
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Wound Care
Assunto da revista:
ENFERMAGEM
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
França