Interventional 4-D C-arm CT perfusion imaging using interleaved scanning and partial reconstruction interpolation.
IEEE Trans Med Imaging
; 31(4): 892-906, 2012 Apr.
Article
em En
| MEDLINE
| ID: mdl-22203707
ABSTRACT
Tissue perfusion measurement during catheter-guided stroke treatment in the interventional suite is currently not possible. In this work, we present a novel approach that uses a C-arm angiography system capable of computed tomography (CT)-like imaging (C-arm CT) for this purpose. With C-arm CT one reconstructed volume can be obtained every 4-6 s which makes it challenging to measure the flow of an injected contrast bolus. We have developed an interleaved scanning (IS) protocol that uses several scan sequences to increase temporal sampling. Using a dedicated 4-D reconstruction approach based on partial reconstruction interpolation (PRI) we can optimally process our data. We evaluated our combined approach (IS-PRI) with simulations and a study in five healthy pigs. In our simulations, the cerebral blood flow values (unit ml/100 g/min) were 60 (healthy tissue) and 20 (pathological tissue). For one scan sequence the values were estimated with standard deviations of 14.3 and 2.9, respectively. For two interleaved sequences the standard deviations decreased to 3.6 and 1.5, respectively. We used perfusion CT to validate the in vivo results. With two interleaved sequences we achieved promising correlations ranging from r=0.63 to r=0.94. The results suggest that C-arm CT tissue perfusion imaging is feasible with two interleaved scan sequences.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Angiografia
/
Intensificação de Imagem Radiográfica
/
Tomografia Computadorizada por Raios X
/
Imagem de Perfusão
Tipo de estudo:
Guideline
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
IEEE Trans Med Imaging
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Alemanha