[Analysis of the binding capacity of the benzodiazepine site of gabaa receptor in mice C57BL/6 and BALB/C pretreated with anxiolytics].
Eksp Klin Farmakol
; 74(8): 3-7, 2011.
Article
em Ru
| MEDLINE
| ID: mdl-22232906
ABSTRACT
The level of specific 3H-flunitrazepam binding in synaptosomal membranes of C57BL/6 and BALB/c mice brain underwent to the stress of different types has been studied. Mild stress (Elevated Plus Maze) was shown to induce the decrease of benzodiazepine binding in BALB/c mice only, while the strong one (Exposure to a predator) was revealed to cause this decrease in both strains. Behavioral effects of different non-benzodiazepine drugs possessing anxiolytic properties (Afobazol, Ladasten and Noopept) was accompanied with the normalization of the level of benzodiazepine reception, reduced by the stress of both modalities.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ansiedade
/
Sinaptossomos
/
Ansiolíticos
/
Encéfalo
/
Receptores de GABA-A
/
Agonistas de Receptores de GABA-A
/
Flunitrazepam
Limite:
Animals
Idioma:
Ru
Revista:
Eksp Klin Farmakol
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article