Human γδ T lymphocytes are licensed for professional antigen presentation by interaction with opsonized target cells.
J Immunol
; 188(4): 1708-16, 2012 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-22250090
ABSTRACT
Activated human blood γδ T cells have also been previously demonstrated to behave as professional APCs, although the processes that control APC function have not been characterized. n this study, we show that the acquisition of potent APC function by human blood γδ T cells is achieved after physical interaction with an Ab-coated target cell, a process that we refer to as licensing. In cancer models, licensing of γδ T cells by tumor-reactive mAbs promotes the uptake of tumor Ags and professional presentation to tumor-reactive αß T cells. We propose that licensing by Ab is a mechanism whereby the adaptive properties of γδ T cells are induced by their innate functions in a spatially and temporally controlled manner.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fagocitose
/
Subpopulações de Linfócitos T
/
Apresentação de Antígeno
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Antígenos de Neoplasias
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
J Immunol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Reino Unido