Hypoxia-inducible factors in physiology and medicine.
Cell
; 148(3): 399-408, 2012 Feb 03.
Article
em En
| MEDLINE
| ID: mdl-22304911
ABSTRACT
Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis in all metazoan species. Rapid progress is being made in elucidating homeostatic roles of HIFs in many physiological systems, determining pathological consequences of HIF dysregulation in chronic diseases, and investigating potential targeting of HIFs for therapeutic purposes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Fatores de Transcrição Hélice-Alça-Hélice Básicos
/
Evolução Biológica
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos