A new iridoid glycoside from the roots of Dipsacus asper.

ABSTRACT

A new iridoid glycoside, named loganic acid ethyl ester (1), together with five known compounds chlorogenic acid (2), caffeic acid (3), loganin (4), cantleyoside (5) and syringaresinol-4',4''-O-bis-ß-D-glucoside (6) were isolated from the roots of Dipsacus asper. The structure of compound 1 was elucidated on the basis of detailed spectroscopic analyses. Lignan is isolated from Dipsacaceae species for the first time. Compounds 1, 4 and 5 had moderate neuroprotective effects against the Aß25₋35 induced cell death in PC12 cells.