Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis.
Blood
; 119(15): 3495-502, 2012 Apr 12.
Article
em En
| MEDLINE
| ID: mdl-22343728
ABSTRACT
In addition to its proapoptotic function, caspase-8 is also important for several other processes, including suppressing necroptosis, cell migration, and immune cell survival. In the present study, we report that the loss of caspase-8 in B lymphocytes leads to B-cell malignancies and that the risk for these tumors is further enhanced in the absence of p53. We also report that deficiency of caspase-8 results in impaired cytokinesis and that casp8(-/-) lymphomas display remarkably elevated levels of chromosomal aberrations. Our data support an important role for caspase-8 in the maintenance of genomic integrity and highlight its tumor-suppressive function.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfoma de Células B
/
Instabilidade Cromossômica
/
Caspase 8
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Blood
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Canadá