Copper-catalyzed di- and trifluoromethylation of α,ß-unsaturated carboxylic acids: a protocol for vinylic fluoroalkylations.

ABSTRACT

Dual action the Lewis acid CuF(2) ⋅2 H(2)O efficiently catalyzes the reaction between electrophilic fluoroalkylating agents and α,ß-unsaturated carboxylic acids by dually activating both reactants, thus affording di- and trifluoromethyl alkenes in high yields with excellent E/Z selectivity.