Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice.
Kidney Int
; 82(1): 26-33, 2012 Jul.
Article
em En
| MEDLINE
| ID: mdl-22418978
ABSTRACT
Corin is a protease that activates atrial natriuretic peptide, a cardiac hormone important in the control of blood pressure and salt-water balance. Here we examined the role of corin in regulating blood pressure and sodium homeostasis upon dietary salt challenge. Radiotelemetry-tracked blood pressure in corin knockout mice on a high-salt diet (4% sodium chloride) was significantly increased; however, there was no such change in similarly treated wild-type mice. In the knockout mice on the high-salt diet there was an impairment of urinary sodium excretion and an increase in body weight, but no elevation of plasma renin or serum aldosterone levels. When the knockout mice on the high-salt diet were treated with amiloride, an epithelial sodium channel blocker that inhibits renal sodium reabsorption, the impaired urinary sodium excretion and increased body weight were normalized. Amiloride treatment also reduced high blood pressure caused by the high-salt diet in these mice. Thus, the lack of corin in mice impairs their adaptive renal response to high dietary salt, suggesting that corin deficiency may represent an important mechanism underlying salt-sensitive hypertension.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pressão Sanguínea
/
Serina Endopeptidases
/
Hipertensão
/
Rim
/
Natriurese
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Idioma:
En
Revista:
Kidney Int
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos