Long-term recovery of irradiated prostate cancer increases cancer stem cells.
Prostate
; 72(16): 1746-56, 2012 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-22513891
ABSTRACT
BACKGROUND:
Despite improvements in treatment, prostate cancer (PC) remains the second-leading cause of cancer death in men. Radiotherapy is among the first-line treatments for PC, but a significant number of patients relapse. Recent evidence supports the idea that PC is initiated by a subset of cells, termed cancer stem cells (CSCs). CSCs have also been implicated in radioresistance in various malignancies, but their role in PC has not yet been investigated.METHODS:
We compared the relative radiosensitivity of isolated CSCs to the total population of their corresponding cell lines, and examined the relative numbers of CSCs in irradiated cell lines following long-term recovery and in recurrent human PC.RESULTS:
Here, we show that while irradiation does not immediately favor increased survival of CSCs, irradiated PC cell lines showed an increase in CSC properties with long-term recovery. These data suggest that, although CSCs are initially damaged by radiation, they possess a greater capacity for recovery and regrowth.CONCLUSIONS:
The combination of radiotherapy with a CSC-targeted therapeutic strategy may prevent tumor recurrence.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Próstata
/
Neoplasias da Próstata
/
Tolerância a Radiação
/
Células-Tronco Neoplásicas
Limite:
Humans
/
Male
Idioma:
En
Revista:
Prostate
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos