BLIMP1α, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
; 156(1): 1-6, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-22580854
ABSTRACT
AIMS:
The aim of this review was to summarize recent knowledge of the structure and function of a transcriptional repressor, B lymphocyte induced maturation protein 1 (BLIMP1) and its participation in the pathogenesis of B lymphomas. METHODS ANDRESULTS:
This review summarizes the structure and function of BLIMP1, its major target genes and its role as a tumour suppressor in B cell lymphomas. We review our recent data implicating the loss of BLIMP1α as an important step in the pathogenesis of the Epstein-Barr virus (EBV) associated B cell lymphomas.CONCLUSIONS:
BLIMP1 is a transcriptional repressor essential for the differentiation of germinal centre (GC) B cells to plasma cells. The loss of BLIMP1 in GC B cells could contribute to the pathogenesis of EBV-associated lymphomas by preventing plasma cell differentiation and viral replication.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmócitos
/
Proteínas Repressoras
/
Diferenciação Celular
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Genes Supressores de Tumor
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Linfoma de Células B
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
Assunto da revista:
MEDICINA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Reino Unido