ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A.
Mitochondrion
; 12(4): 441-8, 2012 Jul.
Article
em En
| MEDLINE
| ID: mdl-22664726
ABSTRACT
Here we report on the identification of a human pluripotent embryonic stem cell (hESC) specific mitochondrial protein that is re-expressed in cancer cells, ATAD3B. ATAD3B belongs to the AAA+ ATPase ATAD3 protein family of mitochondrial proteins specific to multicellular eukaryotes. Using loss- and gain-of-function approaches, we show that ATAD3B associates with the ubiquitous ATAD3A species, negatively regulates the interaction of ATAD3A with matrix nucleoid complexes and contributes to a mitochondria fragmentation phenotype. We conclude that ATAD3B is a negative regulator of ATAD3A and may function as an adaptor of mitochondrial homeostasis and metabolism in hESCs and cancer cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adenosina Trifosfatases
/
Proteínas Mitocondriais
/
Células-Tronco Embrionárias
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Proteínas de Membrana
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Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Mitochondrion
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
França