Mathematical simulation of membrane protein clustering for efficient signal transduction.
Ann Biomed Eng
; 40(11): 2307-18, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-22669501
ABSTRACT
Initiation and propagation of cell signaling depend on productive interactions among signaling proteins at the plasma membrane. These diffusion-limited interactions can be influenced by features of the membrane that introduce barriers, such as cytoskeletal corrals, or microdomains that transiently confine both transmembrane receptors and membrane-tethered peripheral proteins. Membrane topographical features can lead to clustering of receptors and other membrane components, even under very dynamic conditions. This review considers the experimental and mathematical evidence that protein clustering impacts cell signaling in complex ways. Simulation approaches used to consider these stochastic processes are discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Membrana Celular
/
Proteínas de Membrana
/
Modelos Biológicos
Limite:
Humans
Idioma:
En
Revista:
Ann Biomed Eng
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos