Effect of HMG-CoA reductase inhibitors on antimicrobial susceptibilities for gram-negative rods.
J Basic Microbiol
; 53(4): 336-9, 2013 Apr.
Article
em En
| MEDLINE
| ID: mdl-22736455
ABSTRACT
Epidemiologic evidence suggests a beneficial effect of HMG-CoA reductase inhibitors (statins) in sepsis, and in-vitro data exist for antimicrobial activity of statins against some bacteria and fungi. We examined whether statin exposure at physiologic concentrations enhances activity of selected antimicrobials against Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli. Broth microdilution was performed with and without dose-ranging concentrations of lovastatin, fluvastatin, atorvastatin, pravastatin and simvastatin. No effects on antimicrobial activity were demonstrated.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bacilos e Cocos Aeróbios Gram-Negativos
/
Inibidores de Hidroximetilglutaril-CoA Redutases
/
Interações Medicamentosas
/
Antibacterianos
Idioma:
En
Revista:
J Basic Microbiol
Assunto da revista:
MICROBIOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos