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Morphological and functional characteristics of models of experimental myocardial injury induced by isoproterenol.
Nichtova, Zuzana; Novotova, Marta; Kralova, Eva; Stankovicova, Tatiana.
Afiliação
  • Nichtova Z; Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlárska 5, 833 34 Bratislava, Slovak Republic. Nichtova@fpharm.uniba.sk
Gen Physiol Biophys ; 31(2): 141-51, 2012 Jun.
Article em En | MEDLINE | ID: mdl-22781817
ABSTRACT
The animal models of myocardial injury induced by systemic ß-adrenergic receptor agonist administration represent an experimental approach of persisting interest. These models were found useful especially for studies of structural and functional adaptation of myocardium during the progression of cardiac adaptive response towards maladaptive hypertrophy and insufficiency. The pathological alterations induced by isoproterenol (ISO) do not develop evenly. The ISO models may contribute effectively to understanding of pathologies in signal transduction, energetics, excitability and contractility that may contribute concomitantly to cardiac dysfunction and heart failure. In this minireview we focused on the alterations in general characteristics and heart function as well as on the morphological changes of cardiomyocytes developed during ISO administration. The morphological alterations within the cellular macro- and microdomains correspond to the electrical remodelling and contractile dysfunction of ventricular myocardium that could be used to identify pathological changes ranging from hypertrophy to failing heart.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disfunção Ventricular Esquerda / Modelos Animais de Doenças / Sistema de Condução Cardíaco / Isoproterenol / Contração Miocárdica / Miocárdio Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Gen Physiol Biophys Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disfunção Ventricular Esquerda / Modelos Animais de Doenças / Sistema de Condução Cardíaco / Isoproterenol / Contração Miocárdica / Miocárdio Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Gen Physiol Biophys Ano de publicação: 2012 Tipo de documento: Article