Morphological and functional characteristics of models of experimental myocardial injury induced by isoproterenol.
Gen Physiol Biophys
; 31(2): 141-51, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22781817
ABSTRACT
The animal models of myocardial injury induced by systemic ß-adrenergic receptor agonist administration represent an experimental approach of persisting interest. These models were found useful especially for studies of structural and functional adaptation of myocardium during the progression of cardiac adaptive response towards maladaptive hypertrophy and insufficiency. The pathological alterations induced by isoproterenol (ISO) do not develop evenly. The ISO models may contribute effectively to understanding of pathologies in signal transduction, energetics, excitability and contractility that may contribute concomitantly to cardiac dysfunction and heart failure. In this minireview we focused on the alterations in general characteristics and heart function as well as on the morphological changes of cardiomyocytes developed during ISO administration. The morphological alterations within the cellular macro- and microdomains correspond to the electrical remodelling and contractile dysfunction of ventricular myocardium that could be used to identify pathological changes ranging from hypertrophy to failing heart.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Disfunção Ventricular Esquerda
/
Modelos Animais de Doenças
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Sistema de Condução Cardíaco
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Isoproterenol
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Contração Miocárdica
/
Miocárdio
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Gen Physiol Biophys
Ano de publicação:
2012
Tipo de documento:
Article