A method to distinguish between lysine acetylation and lysine methylation from protein sequences.
J Theor Biol
; 310: 223-30, 2012 Oct 07.
Article
em En
| MEDLINE
| ID: mdl-22796329
ABSTRACT
Lysine acetylation and methylation are two major post-translational modifications of lysine residues. They play vital roles in both biological and pathological processes. Specific lysine residues in H3 histone protein tails appear to be targeted for either acetylation or methylation. Hence it is very challenging to distinguish between acetylated and methylated lysine residues using computational methods. This work presents a method that incorporates protein sequence information, secondary structure and amino acid properties to differentiate acetyl-lysine from methyl-lysine. We apply an encoding scheme based on grouped weight and position weight amino acid composition to extract sequence information and physicochemical properties around lysine sites. The proposed method achieves an accuracy of 93.3% using a jackknife test. Feature analysis demonstrates that the prediction model with multiple features can take full advantage of the supplementary information from different features to improve classification performance and prediction robustness. Analysis of the characteristics of lysine residues which can be either methylated or acetylated shows that they are more similar to methyl-lysine than to acetyl-lysine.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Análise de Sequência de Proteína
/
Lisina
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
J Theor Biol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China