Long-term facilitation of ventilation following acute continuous hypoxia in awake humans during sustained hypercapnia.
J Physiol
; 590(20): 5151-65, 2012 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-22826133
ABSTRACT
In awake humans, long-term facilitation of ventilation (vLTF) following acute intermittent hypoxia (AIH) is only expressed if CO2 is maintained above normocapnic levels. vLTF has not been reported following acute continuous hypoxia (ACH) and it is not known whether this might be unmasked by elevated CO2. Twelve healthy participants completed three trials. In all trials end-tidal pressure of CO2 was elevated 4-5 mmHg above normocapnic levels. During Trial 1 (AIH) participants were exposed to eight 4 min episodes of hypoxia. During Trial 2 (ACH) participants were exposed to continuous hypoxia for 32 min. In Trial 3 (Control) participants were exposed to euoxia throughout. To assess the contribution of the carotid body (CB) in observed ventilatory responses, CB afferent discharge before and after each trial was transiently inhibited with hyperoxia. Minute ventilation ( ËV E) increased following all trials, but was significantly greater in Trials 1 and 2 when compared with Trial 3 (Trial 1 4.96 ± 0.87, Trial 2 5.07 ± 0.7, Trial 3 2.55 ± 0.98 l min-1, P < 0.05). Hyperoxia attenuated VE to a similar extent in baseline and recovery in all trials (Trial 1 3.0 ± 0.57 vs. 3.27 ± 0.68, Trial 2 1.97 ± 0.62 vs. 2.56 ± 0.62, Trial 3 2.23 ± 0.49 vs. 2.15 ± 0.55 l min-1, P > 0.05). Data are means ± SEM. In awake humans with elevated CO2, ACH evokes a sustained increase in ventilation that is comparable to that evoked by AIH. However, a gradual positive drift in ventilation in response to elevated CO2 accounts for approximately half of this apparent vLTF. Additionally, our data support the view that the CB is not directly involved in maintaining vLTF.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ventilação Pulmonar
/
Hipercapnia
/
Hipóxia
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
J Physiol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Reino Unido