Assessment of tamsulosin as a potential male contraceptive in healthy volunteers.
Urology
; 80(3): 614-7, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-22840866
ABSTRACT
OBJECTIVE:
To investigate the efficacy and safety of tamsulosin, an α(1A)-adrenoceptor antagonist, as a potential male contraceptive.METHODS:
Forty healthy male volunteers were equally divided into 2 groups, each of which received placebo and tamsulosin sequentially in a crossover manner. Ejaculatory profile was examined 4 to 6 hours after administration and adverse effects were noted.RESULTS:
Anejaculation occurred in all subjects after taking 0.8-mg of tamsulosin. Total functional sperm count was significantly reduced in subjects after taking 0.4-mg of tamsulosin. Six subjects receiving 0.8-mg of tamsulosin complained of tolerated discomfort, which disappeared 10 hours after administration.CONCLUSION:
When administered at 0.8 mg, tamsulosin can cause anejaculation with some transient side effects. Our results imply that tamsulosin and related drugs might potentially be used as male contraceptive agents in the future, which needs more studies to verify.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
/
Anticoncepcionais Masculinos
/
Antagonistas de Receptores Adrenérgicos alfa 1
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Urology
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China