Interruption of a study of cervical ripening with isosorbide mononitrate due to adverse effects.
Clin Exp Obstet Gynecol
; 39(2): 175-80, 2012.
Article
em En
| MEDLINE
| ID: mdl-22905458
ABSTRACT
PURPOSE OF INVESTIGATION The objective of this study was to evaluate cervix length and the presence of cervical gland area (CGA) in ultrasounds performed before and after the administration of vaginal isosorbide mononitrate (IMN) for cervical ripening. METHODS:
We performed an observational, descriptive, and longitudinal study of pregnant patients indicated for labor induction and with a Modified Bishop Score (MBS) lower than six. For cervical ripening, 40 mg of vaginal IMN was administered at 0, 16, and 24 hours after the initiation of cervix preparation.RESULTS:
After enrolling 11 patients, the study had to be discontinued due to adverse effects. Three patients requested that they be withdrawn. Headaches were reported by all patients. Nausea, dizziness, dyspnea, and vomiting were also reported. The average cervical lengths at 0, 16, 24 and 36 hours were 27.6, 27.7, 25.9, and 23.0 mm, respectively. CGA disappeared in one of seven patients.CONCLUSIONS:
The use of IMN appears to increase the MBS, slightly reducing cervical length without altering the appearance of CGA. Considering the importance of maternal wellbeing during labor, the routine use of IMN cannot be recommended for cervical ripening in the third trimester due to the frequency and intensity of side-effects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doadores de Óxido Nítrico
/
Maturidade Cervical
/
Dinitrato de Isossorbida
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Clin Exp Obstet Gynecol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Brasil