Implementing personalized medicine: development of a cost-effective customized pharmacogenetics genotyping array.
Clin Pharmacol Ther
; 92(4): 437-9, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22910441
ABSTRACT
Although there is increasing evidence to support the implementation of pharmacogenetics in certain clinical scenarios, the adoption of this approach has been limited. The advent of preemptive and inexpensive testing of critical pharmacogenetic variants may overcome barriers to adoption. We describe the design of a customized array built for the personalized-medicine programs of the University of Florida and Stanford University. We selected key variants for the array using the clinical annotations of the Pharmacogenomics Knowledgebase (PharmGKB), and we included variants in drug metabolism and transporter genes along with other pharmacogenetically important variants.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Farmacogenética
/
Análise de Sequência com Séries de Oligonucleotídeos
/
Medicina de Precisão
/
Genótipo
Tipo de estudo:
Health_economic_evaluation
Limite:
Humans
Idioma:
En
Revista:
Clin Pharmacol Ther
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos