Tackling autoimmunity with gene therapy.
Chimerism
; 3(3): 1-4, 2012.
Article
em En
| MEDLINE
| ID: mdl-22960575
ABSTRACT
Autoimmune diseases result from an aberrant response of the immune system that target self-tissues. Our understanding of normal immune development has been used to subvert this self-reactivity and involves exposing self-antigen to the developing immune system. This can be achieved through bone marrow derived cells, thus introducing potential clinical application. We have used the mouse model of multiple sclerosis to demonstrate that the transfer of bone marrow encoding a target autoantigen can be used to promote immune tolerance. The process of preconditioning recipients for hematopoietic stem cell transfer is critical for potential human translation. Thus, we have directly addressed if our model can also be applied in non-myeloablative and less toxic conditioning to promote tolerance and reverse established disease. Our studies to date indicate that this can indeed be achieved and that only low levels of chimerism are required to achieve tolerance.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Terapia Genética
/
Quimerismo
/
Esclerose Múltipla
Limite:
Animals
Idioma:
En
Revista:
Chimerism
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Austrália