Asymmetric addition of alkoxy ethynyl anion to chiral N-sulfinyl imines.
Org Lett
; 14(19): 5122-5, 2012 Oct 05.
Article
em En
| MEDLINE
| ID: mdl-22994337
ABSTRACT
The addition of lithiated ynol ethers to chiral N-sulfinyl imines proceeds in high yield and diastereoselectivity. The selectivity is completely reversed by the addition of boron trifluoride. These alkoxypropargyl sulfinamides can be reduced to afford enol ethers, selectively oxidized to busyl derivatives, or the ynol ether can be hydrolyzed to afford ß-amino esters.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
França