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Osteochondritis dissecans knee histology studies have variable findings and theories of etiology.
Shea, Kevin G; Jacobs, John C; Carey, James L; Anderson, Allen F; Oxford, Julia T.
Afiliação
  • Shea KG; St Luke's Sports Medicine, St Luke's Children's Hospital, and Department of Biological Sciences, Boise State University, 109 East Bannock Street, Boise, ID 83712, USA.
Clin Orthop Relat Res ; 471(4): 1127-36, 2013 Apr.
Article em En | MEDLINE | ID: mdl-23054514
BACKGROUND: Although many etiological theories have been proposed for osteochondritis dissecans (OCD), its etiology remains unclear. Histological analysis of the articular cartilage and subchondral bone tissues of OCD lesions can provide useful information about the cellular changes and progression of OCD. Previous research is predominantly comprised of retrospective clinical studies from which limited conclusions can be drawn. QUESTIONS/PURPOSES: The purposes of this study were threefold: (1) Is osteonecrosis a consistent finding in OCD biopsy specimens? (2) Is normal articular cartilage a consistent finding in OCD biopsy specimens? (3) Do histological studies propose an etiology for OCD based on the tissue findings? METHODS: We searched the PubMed, Embase, and CINAHL databases for studies that conducted histological analyses of OCD lesions of the knee and identified 1560 articles. Of these, 11 met our inclusion criteria: a study of OCD lesions about the knee, published in the English language, and performed a histological analysis of subchondral bone and articular cartilage. These 11 studies were assessed for an etiology proposed in the study based on the study findings. RESULTS: Seven of 11 studies reported subchondral bone necrosis. Four studies reported normal articular cartilage, two studies reported degenerated or irregular articular cartilage, and five studies found a combination of normal and degenerated or irregular articular cartilage. Five studies proposed trauma or repetitive stress and two studies proposed poor blood supply as possible etiologies. CONCLUSIONS: We found limited research on histological analysis of OCD lesions of the knee. Future studies with consistent methodology are necessary to draw major conclusions about the histology and progression of OCD lesions. Inconsistent histologic findings have resulted in a lack of consensus regarding the presence of osteonecrosis, whether the necrosis is primary or secondary, the association of cartilage degeneration, and the etiology of OCD. Such studies could use a standardized grading system to allow better comparison of findings.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteocondrite Dissecante / Cartilagem Articular / Articulação do Joelho Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Systematic_reviews Limite: Child / Humans Idioma: En Revista: Clin Orthop Relat Res Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteocondrite Dissecante / Cartilagem Articular / Articulação do Joelho Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Systematic_reviews Limite: Child / Humans Idioma: En Revista: Clin Orthop Relat Res Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos