Genetic-based reference values for angiotensin-converting enzyme (ACE) according to I/D polymorphism in a Spanish population sample.
Clin Chem Lab Med
; 50(10): 1749-53, 2012 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-23089703
ABSTRACT
BACKGROUND:
Serum angiotensin-converting enzyme (ACE) activity has been related to sarcoidosis and other granulomatous diseases. It has been demonstrated that serum ACE activity is influenced by ACE gene I/D polymorphism. The aim of this study was to establish ACE activity reference values according to genotype in a Spanish population to improve diagnostic sensitivity and treatment monitoring in sarcoidosis patients.METHODS:
A sample population of 150 blood donors was included in the study. Serum ACE activity and genotype were determined and the reference intervals, defined as the 95% central range of the population (2.5th-97.5th percentiles) were obtained for all three genotypes (DD, DI, II) and for the entire sample.RESULTS:
Genotype frequencies were 37% DD (n=54), 43% DI (n=63), and 20% II (n=30). Individuals with DD genotype showed the highest ACE activity (mean 39.0 U/L, SD 13.6), ID genotype showed intermediate levels (mean 29.5 U/L, SD 10.2) and II genotype lowest levels (mean 19.1 U/L, SD 4.9). ACE activity differed significantly between these groups F (2144)=33.15, p<0.05. The corresponding reference intervals for ACE activity were 13.3-63.9 U/L in the overall sample, 12.3-65.6 U/L in genotype DD, 9.5-49.5 U/L in DI and 9.6-28.7 in II.CONCLUSIONS:
The preliminary reference values for ACE activity in healthy Spanish individuals according to I/D polymorphism are presented. Significant differences in these values were found between the genotype groups.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Peptidil Dipeptidase A
/
População Branca
Limite:
Adult
/
Aged
/
Female
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Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Clin Chem Lab Med
Assunto da revista:
QUIMICA CLINICA
/
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Espanha