Unlike bone, cartilage regeneration remains elusive.
Science
; 338(6109): 917-21, 2012 Nov 16.
Article
em En
| MEDLINE
| ID: mdl-23161992
ABSTRACT
Articular cartilage was predicted to be one of the first tissues to successfully be regenerated, but this proved incorrect. In contrast, bone (but also vasculature and cardiac tissues) has seen numerous successful reparative approaches, despite consisting of multiple cell and tissue types and, thus, possessing more complex design requirements. Here, we use bone-regeneration successes to highlight cartilage-regeneration challenges such as selecting appropriate cell sources and scaffolds, creating biomechanically suitable tissues, and integrating to native tissue. We also discuss technologies that can address the hurdles of engineering a tissue possessing mechanical properties that are unmatched in human-made materials and functioning in environments unfavorable to neotissue growth.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regeneração
/
Cartilagem Articular
/
Engenharia Tecidual
/
Alicerces Teciduais
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos