Effect of age on the pharmacokinetics of a single daily dose of gentamicin sulfate in healthy foals.
Equine Vet J
; 45(4): 507-11, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23173817
ABSTRACT
REASONS FOR PERFORMING STUDY Therapeutic drug monitoring in a small number of foals of various ages indicates that the standard adult dose of 6.6 mg/kg bwt q. 24 h for gentamicin is too low and a dose of 12 mg/kg bwt has been proposed. The pharmacokinetics of this dosage in foals and the ages at which this higher dose should be used have not previously been investigated. OBJECTIVE:
To determine the effect of age on the pharmacokinetics of a single 12 mg/kg bwt i.v. dose of gentamicin in foals.METHODS:
Six healthy foals were given a single i.v. dose of gentamicin at 1-3 days, 2, 4, 8 and 12 weeks of age. Plasma concentrations were measured using LC-MS/MS.RESULTS:
Elimination half-life (mean ± s.d.) was significantly longer in 1-3-day-old foals (8.2 ± 2.0 h) than in foals 4 weeks of age (3.7 ± 1.5 h) or older. Volume of distribution was significantly higher in 1-3-day-old foals (0.75 ± 0.20 l/kg bwt) than in 8- (0.27 ± 0.10 l/kg bwt) or 12-week-old foals (0.29 ± 0.11 l/kg bwt). Concentrations of gentamicin 1 h after administration were significantly lower in 1-3-day-old foals (20.52 ± 2.07 µg/ml) than in all other age groups (>42.16 ± 17.57 µg/ml). Concentrations of gentamicin 24 h after administration were significantly higher in the 1-3-day-old foals (1.97 ± 0.90 µg/ml) than in all the other age groups (<0.85 ± 0.46 µg/ml).CONCLUSIONS:
The pharmacokinetics of gentamicin change considerably in the first 2 weeks of life. POTENTIAL RELEVANCE Intravenous administration of gentamicin at a dose of 12 mg/kg bwt q. 36 h would be required in foals less than 2 weeks of age. In foals 2 weeks of age or older, a lower dose of 6.6 mg/kg bwt given q. 24 h was predicted to be adequate.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gentamicinas
/
Cavalos
/
Antibacterianos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Equine Vet J
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos