BST-2/tetherin: structural biology, viral antagonism, and immunobiology of a potent host antiviral factor.
Mol Immunol
; 54(2): 132-9, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23274150
ABSTRACT
BST-2 (also known as tetherin, CD317, or HM1.24) was first described as a potent interferon-inducible host antiviral factor nearly five years ago. Since that time, numerous reports have been published regarding the antiviral activity and immunological properties of this protein. BST-2 blocks viral replication by inhibiting enveloped virus budding from the surface of infected cells. To counteract this, most viruses have developed strategies to antagonize BST-2, each employing a unique mechanism. In this review, we summarize the antiviral function, structural biology and immunobiology of BST-2. Taken together, our current understanding of BST-2 suggests potential avenues as well as challenges to exploiting its action in the development of broad spectrum antiviral treatments.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Liberação de Vírus
/
Proteínas Ligadas por GPI
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Immunol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos