Diagnostic strategies to investigate cerebrospinal fluid involvement in haematological malignancies.
Leuk Res
; 37(3): 231-7, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23287431
ABSTRACT
Central nervous system (CNS) involvement is a fatal complication of certain haematological malignancies with an incidence as high as 25% in specific leukaemia/lymphoma subtypes. It is often accompanied by 'occult' cerebrospinal fluid (CSF) involvement at diagnosis, which is frequently missed by conventional cytology examination. Unfortunately, a diagnostic gold standard is yet unavailable since CSF morphology may be negative for malignant cells in up to 45% of patients with suspected meningeal involvement. New technologies such as flow cytometry, molecular genetics and newer biomarkers may improve sensitivity and specificity facilitating the diagnosis of CNS involvement as well as effective prophylaxis and successful treatment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Líquido Cefalorraquidiano
/
Neoplasias do Sistema Nervoso Central
/
Neoplasias Hematológicas
/
Técnicas e Procedimentos Diagnósticos
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Leuk Res
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Itália