Dissecting trafficking and signaling of atypical chemokine receptors.
Methods Enzymol
; 521: 151-68, 2013.
Article
em En
| MEDLINE
| ID: mdl-23351738
ABSTRACT
Atypical chemokine receptors are a distinct subset of chemokine receptors able to modulate immune responses by acting as chemokine decoy/scavengers or transporters. Intracellular trafficking properties sustained by Gαi-independent signaling have emerged as a major determinant of their biological properties, which support continuous uptake, transport, and/or concentration, of the ligands. Here, we are providing methods to study both trafficking and signaling of this class of chemokine receptors focusing on the atypical chemokine receptor D6 that degrades inflammatory CC chemokines.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Microscopia Confocal
/
Receptores CCR10
/
Citometria de Fluxo
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Methods Enzymol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Itália