The characterisation and determinants of quality of life in ANCA associated vasculitis.
Ann Rheum Dis
; 73(1): 207-11, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-23355077
ABSTRACT
OBJECTIVES:
To contextualise and identify the determinants of poor health related quality of life (QOL) among patients with antineutrophil cytoplasm antibody (ANCA) associated vasculitis (AAV).METHODS:
A multicentre AAV case-control study was conducted using two matched groups of population and chronic disease controls. Measures of physical and mental QOL as well as putative bio-psychosocial determinants of QOL impairment were collected. Concurrently, putative clinical QOL determinants were recorded. Conditional logistic regression analyses characterised group differences while multivariable logistic regression identified within-case QOL associations which were further quantified using population attributable risks (PAR).RESULTS:
Cases (n=410) experienced similar QOL to chronic disease controls (n=318) (physical QOL OR 0.7, 95% CI 0.4 to 1.1; mental QOL OR 1.1, 95% CI 0.8 to 1.6). However, they were substantially more likely to report poor QOL compared to general population controls (n=470) (physical QOL OR 7.0, 95% CI 4.4 to 11.1; mental QOL OR 2.5, 95% CI 1.7 to 3.6). A few clinical, but many more bio-psychosocial factors were independently associated with poor QOL. In population terms, fatigue was found to be of principal importance (physical QOL PAR 24.6%; mental QOL PAR 47.4%).CONCLUSIONS:
AAV patients experienced significant QOL impairment compared to the general population, but similar to those with other chronic diseases whose considerable needs are already recognised. Potentially modifiable clinical determinants have been identified; however bio-psychosocial interventions are likely to provide the greater QOL gains in this patient population.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Qualidade de Vida
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Inquéritos e Questionários
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Anticorpos Anticitoplasma de Neutrófilos
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Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ann Rheum Dis
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Reino Unido