Iodine-129 as a protein label for studies of plasma protein turnover and its measurement with neutron activation analysis.

Iodine-129 (t 1/2 = 1.57 x 10(7) y) was used as a protein label for the measurement of the turnover rate of albumin in two human subjects. Plasma samples were assayed for 129I using destructive neutron activation analysis. The experiment entailed an estimated radiation dose of 0.2 muSv to the total body of the subjects. The turnover parameters showed reasonable agreement with literature values. When in a rabbit the catabolism of (129I + 131I)-labeled autologous albumin was followed, the results obtained with both labels agreed well.