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Current status of and future strategies for multimodality treatment of unresectable stage III nonsmall cell lung cancer.
Huber, Rudolf M; Reck, Martin; Thomas, Michael.
Afiliação
  • Huber RM; Dept of Medicine, University of Munich - Campus Innenstadt, and Thoracic Oncology Centre Munich, Munich.
Eur Respir J ; 42(4): 1119-33, 2013 Oct.
Article em En | MEDLINE | ID: mdl-23429914
ABSTRACT
Stage III nonsmall cell lung cancer (NSCLC) encompasses a heterogeneous group of patients, some of whom may be candidates for potentially curative surgery, although for the majority surgery is not an option. Recommended therapy for patients with unresectable stage III disease is concurrent treatment with chemotherapy and thoracic radiotherapy, although even with this dual modality therapy survival remains disappointing. Novel classes of agents including targeted therapies have been shown to improve survival in advanced stage NSCLC, raising the possibility that these agents may have benefits in multimodal therapy when combined with chemoradiotherapy. Here we consider the rationale for combining new agents with chemoradiotherapy and the evidence from clinical studies assessing multimodal strategies for the management of patients with unresectable stage III NSCLC.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia Combinada / Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Limite: Humans Idioma: En Revista: Eur Respir J Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia Combinada / Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Limite: Humans Idioma: En Revista: Eur Respir J Ano de publicação: 2013 Tipo de documento: Article