Liposome encapsulated MnCl2 as a liver specific contrast agent for magnetic resonance imaging.
Invest Radiol
; 25(5): 545-51, 1990 May.
Article
em En
| MEDLINE
| ID: mdl-2345086
ABSTRACT
We examined the usefulness of MnCl2 entrapped in liposomes as a liver specific contrast agent for magnetic resonance imaging. Toxicity experiments showed that the effective dose for imaging experiments was 7 to 11 times lower than the LD50 of free MnCl2. In rats with implanted liver tumors, liposome encapsulated MnCl2 caused a two- to three-fold increase in the relaxation rate of the liver while having little effect on the relaxation rate of tumor tissue. T1 weighted, magnetic resonance images obtained at 0.5 T of an R3230 adenocarcinoma implanted in the liver showed an increase in the signal intensity of both normal liver and tumor tissue after the injection of free MnCl2 (25 mumole/kg). However, after the injection of liposome encapsulated MnCl2 (40 mumole/kg) the liver exhibited a marked increase in signal intensity with little change in the signal intensity of the tumor tissue. These results suggest that liposome encapsulated MnCl2 has excellent potential as a liver specific contrast agent for the improved detection of liver metastases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
/
Cloretos
/
Compostos de Manganês
/
Meios de Contraste
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Neoplasias Hepáticas Experimentais
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Manganês
Limite:
Animals
Idioma:
En
Revista:
Invest Radiol
Ano de publicação:
1990
Tipo de documento:
Article