Worsening of contact dermatitis by oral hydroxyzine: a case report.
Dermatol Online J
; 19(2): 4, 2013 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-23473274
ABSTRACT
Hydroxyzine is commonly used to treat pruritic skin lesions. Although rare, hydroxyzine can sometimes be linked to worsening dermatitis in patients who have sensitivities to phenothiazines and/or ethylenediamines. Herein we describe a patient who developed papulovesicular eruptions following the use of topical neomycin. Our patient's contact dermatitis initially improved after the use of oral steroids. However, the patient's skin condition was exacerbated by the continued use of hydroxyzine to treat her pruritus. Patch testing was positive at 48 hours for neomycin sulfate, ethylenediamine dihydrochloride, and p-phenylenediamine. Given the suspected cross-reactivity between hydroxyzine and ethylenediamine, hydroxyzine was discontinued and the patient's cutaneous symptoms improved. In summary, physicians must be aware that oral hydroxyzine can worsen contact dermatitis in ethylenediamine-sensitive patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neomicina
/
Dermatite de Contato
/
Hipersensibilidade a Drogas
/
Hidroxizina
/
Antibacterianos
/
Antipruriginosos
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Dermatol Online J
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos