Touching base with PARPs: moonlighting in the repair of UV lesions and double-strand breaks.
Trends Biochem Sci
; 38(6): 321-30, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23562323
ABSTRACT
Distinct types of DNA damage elicit signaling and repair pathways that counteract the adverse effect of DNA lesions to maintain genome stability. The negatively charged polymer poly(ADP-ribose), which is catalyzed by poly(ADP-ribose) polymerase (PARP) enzymes, is a post-translational modification that serves as a chromatin-based platform for the recruitment of a variety of repair factors and chromatin-remodeling enzymes. Recent work implicates PARP3 in the efficient joining of DNA double-strand breaks during non-homologous end-joining (NHEJ), whereas PARP1 modulates the repair of UV-induced DNA lesions. Here we discuss emerging roles of PARP enzymes in mechanistically distinct DNA repair pathways and highlight unresolved issues and questions for future research.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Raios Ultravioleta
/
Dano ao DNA
/
Poli(ADP-Ribose) Polimerases
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Reparo do DNA
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Holanda