Helicobacter pylori in gastric carcinogenesis: mechanisms.
Gastroenterol Clin North Am
; 42(2): 285-98, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23639641
ABSTRACT
Helicobacter pylori infection induces chronic inflammation and is the strongest known risk factor for gastric cancer. The genomes of H pylori are highly diverse and therefore bacterial virulence factors play an important role in determining the outcome of H pylori infection, in combination with host responses that are augmented by environmental and dietary risk factors. It is important to gain further understanding of the pathogenesis of H pylori infection to develop more effective treatments for this common but deadly malignancy. This review focuses on the specific mechanisms used by H pylori to drive gastric carcinogenesis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Proteínas da Membrana Bacteriana Externa
/
Helicobacter pylori
/
Infecções por Helicobacter
/
Fatores de Virulência
/
Carcinogênese
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Gastroenterol Clin North Am
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos