Synaptotagmins 1 and 2 as mediators of rapid exocytosis at nerve terminals: the dyad hypothesis.
J Theor Biol
; 332: 149-60, 2013 Sep 07.
Article
em En
| MEDLINE
| ID: mdl-23648184
ABSTRACT
The dyad model was developed to explain the extremely rapid kinetics of synaptic vesicle exocytosis. In contrast to most hypotheses which invoke interactions among synaptotagmins, SNAREs and other regulatory molecules, the dyad model features a quartet of synaptotagmins arrayed at the synaptic vesicle-plasma membrane interface. Ca(2+)-triggered movements of these synaptotagmins initiate a sequence of events culminating in the fusion of the vesicular and plasma membranes. The relative simplicity of this model and its amenability to empirical testing provide a useful template for future investigations of the molecular events underlying the exocytotic cascade.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vesículas Sinápticas
/
Membrana Celular
/
Sinaptotagmina I
/
Sinaptotagmina II
/
Exocitose
/
Modelos Neurológicos
Limite:
Animals
Idioma:
En
Revista:
J Theor Biol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos