[Fatal fulminant hepatitis in 2 women taking toloxatone (Humoryl)]. / Hépatites fulminantes mortelles chez deux femmes prenant de la toloxatone (Humoryl).
Gastroenterol Clin Biol
; 14(5): 504-6, 1990.
Article
em Fr
| MEDLINE
| ID: mdl-2365178
ABSTRACT
We report two cases of fulminant hepatitis which might be due to toloxatone, a new type-A monoamine oxidase inhibitor. Hepatitis occurred 20 days after the beginning of toloxatone administration in the first case and 138 days after the reintroduction of treatment in the second case. Clinical features included vomiting and jaundice, followed by asterixis and coma. Histologically, hepatic cell necrosis was predominant in the centrilobular area in the first case, and affected the entire lobule in the second case. Both patients died despite emergency liver transplantation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxazóis
/
Oxazolidinonas
/
Doença Hepática Induzida por Substâncias e Drogas
/
Antidepressivos
Limite:
Adult
/
Female
/
Humans
Idioma:
Fr
Revista:
Gastroenterol Clin Biol
Ano de publicação:
1990
Tipo de documento:
Article